Rumpus definition, a noisy or violent disturbance; commotion; uproar: There was a terrible rumpus going on upstairs. Rumpus definition: If someone or something causes a rumpus, they cause a lot of noise or argument. Meaning, pronunciation, translations and examples. ‘The Munali rumpus is a warning that their actions can generate reactions that only help to aggravate the situation and estrange them from an otherwise sympathetic public.’ ‘Students entering the dining hall made an eager rumpus.’.
Vascular Ehlers Danlos syndrome (vEDS) is the severe subtype of Ehlers-Danlos Syndrome, affecting 1 in 50,000 people worldwide and results from pathogenic variants in the COL3A1 gene, which encodes the chains of type III procollagen, a major protein in vessel walls and hollow organs. Twenty-five percent of vEDS patients have a first complication by the age of 20 years, and more than eighty percent have at least one complication by the age of 40. vEDS is a devastating condition, and vEDS patients have a median lifespan of 51 years. There are no FDA-approved therapies for vEDS.
Define Rumpus
Rumpus
Enzastaurin is an orally available investigational first-in-class small molecule, serine/threonine kinase inhibitor of the PKC beta, PI3K and AKT pathways. It has been studied in more than 3,300 patients across a range of solid and hematological tumor types. Research in vascular Ehlers-Danlos Syndrome has implicated the PCK pathway with PKC inhibition as a potential treatment option.